Frontotemporal dementia and its subtypes: a genome-wide association study
Identifieur interne : 003934 ( Main/Exploration ); précédent : 003933; suivant : 003935Frontotemporal dementia and its subtypes: a genome-wide association study
Auteurs : Raffaele Ferrari ; Dena G. Hernandez ; Michael A. Nalls ; Jonathan D. Rohrer ; Adaikalavan Ramasamy ; John B J. Kwok ; Carol Dobson-Stone ; William S. Brooks ; Peter R. Schofield ; Glenda M. Halliday ; John R. Hodges ; Olivier Piguet ; Lauren Bartley ; Elizabeth Thompson ; Eric Haan ; Isabel Hernández ; Agustín Ruiz ; Mercè Boada ; Barbara Borroni ; Alessandro Padovani ; Carlos Cruchaga ; Nigel J. Cairns ; Luisa Benussi ; Giuliano Binetti ; Roberta Ghidoni ; Gianluigi Forloni ; Daniela Galimberti ; Chiara Fenoglio ; Maria Serpente ; Elio Scarpini ; Jordi Clarim N ; Alberto Lle ; Rafael Blesa ; Maria Landqvist Waldö ; Karin Nilsson ; Christer Nilsson ; Ian R A. Mackenzie ; Ging-Yuek R. Hsiung ; David M A. Mann ; Jordan Grafman ; Christopher M. Morris ; Johannes Attems ; Timothy D. Griffiths ; Ian G. Mckeith ; Alan J. Thomas ; P. Pietrini ; Edward D. Huey ; Eric M. Wassermann ; Atik Baborie ; Evelyn Jaros ; Michael C. Tierney ; Pau Pastor ; Cristina Razquin ; Sara Ortega-Cubero ; Elena Alonso ; Robert Perneczky ; Janine Diehl-Schmid ; Panagiotis Alexopoulos ; Alexander Kurz ; Innocenzo Rainero ; Elisa Rubino ; Lorenzo Pinessi ; Ekaterina Rogaeva ; Peter St George-Hyslop ; Giacomina Rossi ; Fabrizio Tagliavini ; Giorgio Giaccone ; James B. Rowe ; J C M. Schlachetzki ; James Uphill ; John Collinge ; S. Mead ; Adrian Danek ; Vivianna M. Van Deerlin ; Murray Grossman ; John Q. Trojanowsk ; Julie Van Der Zee ; William Deschamps ; Tim Van Langenhove ; Marc Cruts ; Christine Van Broeckhoven ; Stefano F. Cappa ; Isabelle Le Ber ; Didier Hannequin ; Véronique Golfier ; Martine Vercelletto ; Alexis Brice ; Benedetta Nacmias ; Sandro Sorbi ; Silvia Bagnoli ; Irene Piaceri ; J Rgen E. Nielsen ; Lena E. Hjermind ; Matthias Riemenschneider ; Manuel Mayhaus ; Bernd Ibach ; Gilles Gasparoni ; Sabrina Pichler ; Wei Gu ; Martin N. Rossor ; Nick C. Fox ; Jason D. Warren ; Maria Grazia Spillantini ; Huw R. Morris ; Patrizia Rizzu ; Peter Heutink ; Julie S. Snowden ; Sara Rollinson ; Anna Richardson ; Alexander Gerhard ; Amalia C. Bruni ; Raffaele Maletta ; Francesca Frangipane ; Chiara Cupidi ; Livia Bernardi ; Maria Anfossi ; Maura Gallo ; Maria Elena Conidi ; Nicoletta Smirne ; Rosa Rademakers ; Matt Baker ; Dennis W. Dickson ; Neill R. Graff-Radford ; Ronald C. Petersen ; David Knopman ; Keith A. Josephs ; Bradley F. Boeve ; Joseph E. Parisi ; William W. Seeley ; Bruce L. Miller ; Anna M. Karydas ; Howard Rosen ; John C. Van Swieten ; Elise G P. Dopper ; Harro Seelaar ; Yolande Al Pijnenburg ; Philip Scheltens ; Giancarlo Logroscino ; Rosa Capozzo ; Valeria Novelli ; Annibale A. Puca ; M. Franceschi ; Alfredo Postiglione ; Graziella Milan ; Paolo Sorrentino ; Mark Kristiansen ; Huei-Hsin Chiang ; Caroline Graff ; Florence Pasquier ; Adeline Rollin ; Vincent Deramecourt ; Florence Lebert ; Dimitrios Kapogiannis ; Luigi Ferrucci ; Stuart Pickering-Brown ; Andrew B. Singleton ; John Hardy ; Parastoo MomeniSource :
- Lancet neurology [ 1474-4422 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Démence frontotemporale.
- génétique : Démence frontotemporale.
- Adulte, Adulte d'âge moyen, Démence frontotemporale, Femelle, Génotype, Humains, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Étude d'association pangénomique.
English descriptors
- KwdEn :
- MESH :
- classification : Frontotemporal Dementia.
- diagnosis : Frontotemporal Dementia.
- genetics : Frontotemporal Dementia.
- methods : Genome-Wide Association Study.
- Adult, Aged, Aged, 80 and over, Female, Genotype, Humans, Male, Middle Aged.
Abstract
Frontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological signatures, and genetic variability. Mutations in three genes—
We did a two-stage genome-wide association study on clinical FTD, analysing samples from 3526 patients with FTD and 9402 healthy controls. All participants had European ancestry. In the discovery phase (samples from 2154 patients with FTD and 4308 controls), we did separate association analyses for each FTD subtype (behavioural variant FTD, semantic dementia, progressive non-fluent aphasia, and FTD overlapping with motor neuron disease [FTD-MND]), followed by a meta-analysis of the entire dataset. We carried forward replication of the novel suggestive loci in an independent sample series (samples from 1372 patients and 5094 controls) and then did joint phase and brain expression and methylation quantitative trait loci analyses for the associated (p<5 × 10−8) and suggestive single-nucleotide polymorphisms.
We identified novel associations exceeding the genome-wide significance threshold (p<5 × 10−8) that encompassed the
Our findings suggest that immune system processes (link to 6p21.3) and possibly lysosomal and autophagy pathways (link to 11q14) are potentially involved in FTD. Our findings need to be replicated to better define the association of the newly identified loci with disease and possibly to shed light on the pathomechanisms contributing to FTD.
The National Institute of Neurological Disorders and Stroke and National Institute on Aging, the Wellcome/ MRC Centre on Parkinson’s disease, Alzheimer’s Research UK, and Texas Tech University Health Sciences Center.
Url:
DOI: 10.1016/S1474-4422(14)70065-1
PubMed: 24943344
PubMed Central: 4112126
Affiliations:
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Trojanowsk</name></author><author><name sortKey="Van Der Zee, Julie" sort="Van Der Zee, Julie" uniqKey="Van Der Zee J" first="Julie" last="Van Der Zee">Julie Van Der Zee</name></author><author><name sortKey="Deschamps, William" sort="Deschamps, William" uniqKey="Deschamps W" first="William" last="Deschamps">William Deschamps</name></author><author><name sortKey="Van Langenhove, Tim" sort="Van Langenhove, Tim" uniqKey="Van Langenhove T" first="Tim" last="Van Langenhove">Tim Van Langenhove</name></author><author><name sortKey="Cruts, Marc" sort="Cruts, Marc" uniqKey="Cruts M" first="Marc" last="Cruts">Marc Cruts</name></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name></author><author><name sortKey="Cappa, Stefano F" sort="Cappa, Stefano F" uniqKey="Cappa S" first="Stefano F" last="Cappa">Stefano F. Cappa</name></author><author><name sortKey="Le Ber, Isabelle" sort="Le Ber, Isabelle" uniqKey="Le Ber I" first="Isabelle" last="Le Ber">Isabelle Le Ber</name></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name></author><author><name sortKey="Golfier, Veronique" sort="Golfier, Veronique" uniqKey="Golfier V" first="Véronique" last="Golfier">Véronique Golfier</name></author><author><name sortKey="Vercelletto, Martine" sort="Vercelletto, Martine" uniqKey="Vercelletto M" first="Martine" last="Vercelletto">Martine Vercelletto</name></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name></author><author><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name></author><author><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name></author><author><name sortKey="Bagnoli, Silvia" sort="Bagnoli, Silvia" uniqKey="Bagnoli S" first="Silvia" last="Bagnoli">Silvia Bagnoli</name></author><author><name sortKey="Piaceri, Irene" sort="Piaceri, Irene" uniqKey="Piaceri I" first="Irene" last="Piaceri">Irene Piaceri</name></author><author><name sortKey="Nielsen, J Rgen E" sort="Nielsen, J Rgen E" uniqKey="Nielsen J" first="J Rgen E" last="Nielsen">J Rgen E. Nielsen</name></author><author><name sortKey="Hjermind, Lena E" sort="Hjermind, Lena E" uniqKey="Hjermind L" first="Lena E" last="Hjermind">Lena E. Hjermind</name></author><author><name sortKey="Riemenschneider, Matthias" sort="Riemenschneider, Matthias" uniqKey="Riemenschneider M" first="Matthias" last="Riemenschneider">Matthias Riemenschneider</name></author><author><name sortKey="Mayhaus, Manuel" sort="Mayhaus, Manuel" uniqKey="Mayhaus M" first="Manuel" last="Mayhaus">Manuel Mayhaus</name></author><author><name sortKey="Ibach, Bernd" sort="Ibach, Bernd" uniqKey="Ibach B" first="Bernd" last="Ibach">Bernd Ibach</name></author><author><name sortKey="Gasparoni, Gilles" sort="Gasparoni, Gilles" uniqKey="Gasparoni G" first="Gilles" last="Gasparoni">Gilles Gasparoni</name></author><author><name sortKey="Pichler, Sabrina" sort="Pichler, Sabrina" uniqKey="Pichler S" first="Sabrina" last="Pichler">Sabrina Pichler</name></author><author><name sortKey="Gu, Wei" sort="Gu, Wei" uniqKey="Gu W" first="Wei" last="Gu">Wei Gu</name></author><author><name sortKey="Rossor, Martin N" sort="Rossor, Martin N" uniqKey="Rossor M" first="Martin N" last="Rossor">Martin N. Rossor</name></author><author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C" last="Fox">Nick C. Fox</name></author><author><name sortKey="Warren, Jason D" sort="Warren, Jason D" uniqKey="Warren J" first="Jason D" last="Warren">Jason D. Warren</name></author><author><name sortKey="Spillantini, Maria Grazia" sort="Spillantini, Maria Grazia" uniqKey="Spillantini M" first="Maria Grazia" last="Spillantini">Maria Grazia Spillantini</name></author><author><name sortKey="Morris, Huw R" sort="Morris, Huw R" uniqKey="Morris H" first="Huw R" last="Morris">Huw R. Morris</name></author><author><name sortKey="Rizzu, Patrizia" sort="Rizzu, Patrizia" uniqKey="Rizzu P" first="Patrizia" last="Rizzu">Patrizia Rizzu</name></author><author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name></author><author><name sortKey="Snowden, Julie S" sort="Snowden, Julie S" uniqKey="Snowden J" first="Julie S" last="Snowden">Julie S. Snowden</name></author><author><name sortKey="Rollinson, Sara" sort="Rollinson, Sara" uniqKey="Rollinson S" first="Sara" last="Rollinson">Sara Rollinson</name></author><author><name sortKey="Richardson, Anna" sort="Richardson, Anna" uniqKey="Richardson A" first="Anna" last="Richardson">Anna Richardson</name></author><author><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name></author><author><name sortKey="Bruni, Amalia C" sort="Bruni, Amalia C" uniqKey="Bruni A" first="Amalia C" last="Bruni">Amalia C. Bruni</name></author><author><name sortKey="Maletta, Raffaele" sort="Maletta, Raffaele" uniqKey="Maletta R" first="Raffaele" last="Maletta">Raffaele Maletta</name></author><author><name sortKey="Frangipane, Francesca" sort="Frangipane, Francesca" uniqKey="Frangipane F" first="Francesca" last="Frangipane">Francesca Frangipane</name></author><author><name sortKey="Cupidi, Chiara" sort="Cupidi, Chiara" uniqKey="Cupidi C" first="Chiara" last="Cupidi">Chiara Cupidi</name></author><author><name sortKey="Bernardi, Livia" sort="Bernardi, Livia" uniqKey="Bernardi L" first="Livia" last="Bernardi">Livia Bernardi</name></author><author><name sortKey="Anfossi, Maria" sort="Anfossi, Maria" uniqKey="Anfossi M" first="Maria" last="Anfossi">Maria Anfossi</name></author><author><name sortKey="Gallo, Maura" sort="Gallo, Maura" uniqKey="Gallo M" first="Maura" last="Gallo">Maura Gallo</name></author><author><name sortKey="Conidi, Maria Elena" sort="Conidi, Maria Elena" uniqKey="Conidi M" first="Maria Elena" last="Conidi">Maria Elena Conidi</name></author><author><name sortKey="Smirne, Nicoletta" sort="Smirne, Nicoletta" uniqKey="Smirne N" first="Nicoletta" last="Smirne">Nicoletta Smirne</name></author><author><name sortKey="Rademakers, Rosa" sort="Rademakers, Rosa" uniqKey="Rademakers R" first="Rosa" last="Rademakers">Rosa Rademakers</name></author><author><name sortKey="Baker, Matt" sort="Baker, Matt" uniqKey="Baker M" first="Matt" last="Baker">Matt Baker</name></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name></author><author><name sortKey="Graff Radford, Neill R" sort="Graff Radford, Neill R" uniqKey="Graff Radford N" first="Neill R" last="Graff-Radford">Neill R. Graff-Radford</name></author><author><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C" last="Petersen">Ronald C. Petersen</name></author><author><name sortKey="Knopman, David" sort="Knopman, David" uniqKey="Knopman D" first="David" last="Knopman">David Knopman</name></author><author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A" last="Josephs">Keith A. Josephs</name></author><author><name sortKey="Boeve, Bradley F" sort="Boeve, Bradley F" uniqKey="Boeve B" first="Bradley F" last="Boeve">Bradley F. Boeve</name></author><author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E" last="Parisi">Joseph E. Parisi</name></author><author><name sortKey="Seeley, William W" sort="Seeley, William W" uniqKey="Seeley W" first="William W" last="Seeley">William W. Seeley</name></author><author><name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L" last="Miller">Bruce L. Miller</name></author><author><name sortKey="Karydas, Anna M" sort="Karydas, Anna M" uniqKey="Karydas A" first="Anna M" last="Karydas">Anna M. Karydas</name></author><author><name sortKey="Rosen, Howard" sort="Rosen, Howard" uniqKey="Rosen H" first="Howard" last="Rosen">Howard Rosen</name></author><author><name sortKey="Van Swieten, John C" sort="Van Swieten, John C" uniqKey="Van Swieten J" first="John C" last="Van Swieten">John C. Van Swieten</name></author><author><name sortKey="Dopper, Elise G P" sort="Dopper, Elise G P" uniqKey="Dopper E" first="Elise G P" last="Dopper">Elise G P. Dopper</name></author><author><name sortKey="Seelaar, Harro" sort="Seelaar, Harro" uniqKey="Seelaar H" first="Harro" last="Seelaar">Harro Seelaar</name></author><author><name sortKey="Pijnenburg, Yolande Al" sort="Pijnenburg, Yolande Al" uniqKey="Pijnenburg Y" first="Yolande Al" last="Pijnenburg">Yolande Al Pijnenburg</name></author><author><name sortKey="Scheltens, Philip" sort="Scheltens, Philip" uniqKey="Scheltens P" first="Philip" last="Scheltens">Philip Scheltens</name></author><author><name sortKey="Logroscino, Giancarlo" sort="Logroscino, Giancarlo" uniqKey="Logroscino G" first="Giancarlo" last="Logroscino">Giancarlo Logroscino</name></author><author><name sortKey="Capozzo, Rosa" sort="Capozzo, Rosa" uniqKey="Capozzo R" first="Rosa" last="Capozzo">Rosa Capozzo</name></author><author><name sortKey="Novelli, Valeria" sort="Novelli, Valeria" uniqKey="Novelli V" first="Valeria" last="Novelli">Valeria Novelli</name></author><author><name sortKey="Puca, Annibale A" sort="Puca, Annibale A" uniqKey="Puca A" first="Annibale A" last="Puca">Annibale A. Puca</name></author><author><name sortKey="Franceschi, M" sort="Franceschi, M" uniqKey="Franceschi M" first="M" last="Franceschi">M. Franceschi</name></author><author><name sortKey="Postiglione, Alfredo" sort="Postiglione, Alfredo" uniqKey="Postiglione A" first="Alfredo" last="Postiglione">Alfredo Postiglione</name></author><author><name sortKey="Milan, Graziella" sort="Milan, Graziella" uniqKey="Milan G" first="Graziella" last="Milan">Graziella Milan</name></author><author><name sortKey="Sorrentino, Paolo" sort="Sorrentino, Paolo" uniqKey="Sorrentino P" first="Paolo" last="Sorrentino">Paolo Sorrentino</name></author><author><name sortKey="Kristiansen, Mark" sort="Kristiansen, Mark" uniqKey="Kristiansen M" first="Mark" last="Kristiansen">Mark Kristiansen</name></author><author><name sortKey="Chiang, Huei Hsin" sort="Chiang, Huei Hsin" uniqKey="Chiang H" first="Huei-Hsin" last="Chiang">Huei-Hsin Chiang</name></author><author><name sortKey="Graff, Caroline" sort="Graff, Caroline" uniqKey="Graff C" first="Caroline" last="Graff">Caroline Graff</name></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name></author><author><name sortKey="Rollin, Adeline" sort="Rollin, Adeline" uniqKey="Rollin A" first="Adeline" last="Rollin">Adeline Rollin</name></author><author><name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name></author><author><name sortKey="Lebert, Florence" sort="Lebert, Florence" uniqKey="Lebert F" first="Florence" last="Lebert">Florence Lebert</name></author><author><name sortKey="Kapogiannis, Dimitrios" sort="Kapogiannis, Dimitrios" uniqKey="Kapogiannis D" first="Dimitrios" last="Kapogiannis">Dimitrios Kapogiannis</name></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name></author><author><name sortKey="Pickering Brown, Stuart" sort="Pickering Brown, Stuart" uniqKey="Pickering Brown S" first="Stuart" last="Pickering-Brown">Stuart Pickering-Brown</name></author><author><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B" last="Singleton">Andrew B. Singleton</name></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name></author><author><name sortKey="Momeni, Parastoo" sort="Momeni, Parastoo" uniqKey="Momeni P" first="Parastoo" last="Momeni">Parastoo Momeni</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24943344</idno><idno type="pmc">4112126</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112126</idno><idno type="RBID">PMC:4112126</idno><idno type="doi">10.1016/S1474-4422(14)70065-1</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001E07</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E07</idno><idno type="wicri:Area/Pmc/Curation">001C63</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001C63</idno><idno type="wicri:Area/Pmc/Checkpoint">001583</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001583</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">003657</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003657</idno><idno type="wicri:Area/PubMed/Curation">003544</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003544</idno><idno type="wicri:Area/PubMed/Checkpoint">003544</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003544</idno><idno type="wicri:Area/Ncbi/Merge">001B36</idno><idno type="wicri:Area/Ncbi/Curation">001B36</idno><idno type="wicri:Area/Ncbi/Checkpoint">001B36</idno><idno type="wicri:doubleKey">1474-4422:2014:Ferrari R:frontotemporal:dementia:and</idno><idno type="wicri:Area/Main/Merge">003970</idno><idno type="wicri:Area/Main/Curation">003934</idno><idno type="wicri:Area/Main/Exploration">003934</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Frontotemporal dementia and its subtypes: a genome-wide association study</title><author><name sortKey="Ferrari, Raffaele" sort="Ferrari, Raffaele" uniqKey="Ferrari R" first="Raffaele" last="Ferrari">Raffaele Ferrari</name></author><author><name sortKey="Hernandez, Dena G" sort="Hernandez, Dena G" uniqKey="Hernandez D" first="Dena G" last="Hernandez">Dena G. Hernandez</name></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A" last="Nalls">Michael A. Nalls</name></author><author><name sortKey="Rohrer, Jonathan D" sort="Rohrer, Jonathan D" uniqKey="Rohrer J" first="Jonathan D" last="Rohrer">Jonathan D. Rohrer</name></author><author><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name></author><author><name sortKey="Kwok, John B J" sort="Kwok, John B J" uniqKey="Kwok J" first="John B J" last="Kwok">John B J. Kwok</name></author><author><name sortKey="Dobson Stone, Carol" sort="Dobson Stone, Carol" uniqKey="Dobson Stone C" first="Carol" last="Dobson-Stone">Carol Dobson-Stone</name></author><author><name sortKey="Brooks, William S" sort="Brooks, William S" uniqKey="Brooks W" first="William S" last="Brooks">William S. Brooks</name></author><author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R" last="Schofield">Peter R. Schofield</name></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M" last="Halliday">Glenda M. Halliday</name></author><author><name sortKey="Hodges, John R" sort="Hodges, John R" uniqKey="Hodges J" first="John R" last="Hodges">John R. Hodges</name></author><author><name sortKey="Piguet, Olivier" sort="Piguet, Olivier" uniqKey="Piguet O" first="Olivier" last="Piguet">Olivier Piguet</name></author><author><name sortKey="Bartley, Lauren" sort="Bartley, Lauren" uniqKey="Bartley L" first="Lauren" last="Bartley">Lauren Bartley</name></author><author><name sortKey="Thompson, Elizabeth" sort="Thompson, Elizabeth" uniqKey="Thompson E" first="Elizabeth" last="Thompson">Elizabeth Thompson</name></author><author><name sortKey="Haan, Eric" sort="Haan, Eric" uniqKey="Haan E" first="Eric" last="Haan">Eric Haan</name></author><author><name sortKey="Hernandez, Isabel" sort="Hernandez, Isabel" uniqKey="Hernandez I" first="Isabel" last="Hernández">Isabel Hernández</name></author><author><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustín" last="Ruiz">Agustín Ruiz</name></author><author><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name></author><author><name sortKey="Borroni, Barbara" sort="Borroni, Barbara" uniqKey="Borroni B" first="Barbara" last="Borroni">Barbara Borroni</name></author><author><name sortKey="Padovani, Alessandro" sort="Padovani, Alessandro" uniqKey="Padovani A" first="Alessandro" last="Padovani">Alessandro Padovani</name></author><author><name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name></author><author><name sortKey="Cairns, Nigel J" sort="Cairns, Nigel J" uniqKey="Cairns N" first="Nigel J" last="Cairns">Nigel J. Cairns</name></author><author><name sortKey="Benussi, Luisa" sort="Benussi, Luisa" uniqKey="Benussi L" first="Luisa" last="Benussi">Luisa Benussi</name></author><author><name sortKey="Binetti, Giuliano" sort="Binetti, Giuliano" uniqKey="Binetti G" first="Giuliano" last="Binetti">Giuliano Binetti</name></author><author><name sortKey="Ghidoni, Roberta" sort="Ghidoni, Roberta" uniqKey="Ghidoni R" first="Roberta" last="Ghidoni">Roberta Ghidoni</name></author><author><name sortKey="Forloni, Gianluigi" sort="Forloni, Gianluigi" uniqKey="Forloni G" first="Gianluigi" last="Forloni">Gianluigi Forloni</name></author><author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name></author><author><name sortKey="Fenoglio, Chiara" sort="Fenoglio, Chiara" uniqKey="Fenoglio C" first="Chiara" last="Fenoglio">Chiara Fenoglio</name></author><author><name sortKey="Serpente, Maria" sort="Serpente, Maria" uniqKey="Serpente M" first="Maria" last="Serpente">Maria Serpente</name></author><author><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name></author><author><name sortKey="Clarim N, Jordi" sort="Clarim N, Jordi" uniqKey="Clarim N J" first="Jordi" last="Clarim N">Jordi Clarim N</name></author><author><name sortKey="Lle, Alberto" sort="Lle, Alberto" uniqKey="Lle A" first="Alberto" last="Lle">Alberto Lle</name></author><author><name sortKey="Blesa, Rafael" sort="Blesa, Rafael" uniqKey="Blesa R" first="Rafael" last="Blesa">Rafael Blesa</name></author><author><name sortKey="Waldo, Maria Landqvist" sort="Waldo, Maria Landqvist" uniqKey="Waldo M" first="Maria Landqvist" last="Waldö">Maria Landqvist Waldö</name></author><author><name sortKey="Nilsson, Karin" sort="Nilsson, Karin" uniqKey="Nilsson K" first="Karin" last="Nilsson">Karin Nilsson</name></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name></author><author><name sortKey="Mackenzie, Ian R A" sort="Mackenzie, Ian R A" uniqKey="Mackenzie I" first="Ian R A" last="Mackenzie">Ian R A. Mackenzie</name></author><author><name sortKey="Hsiung, Ging Yuek R" sort="Hsiung, Ging Yuek R" uniqKey="Hsiung G" first="Ging-Yuek R" last="Hsiung">Ging-Yuek R. Hsiung</name></author><author><name sortKey="Mann, David M A" sort="Mann, David M A" uniqKey="Mann D" first="David M A" last="Mann">David M A. Mann</name></author><author><name sortKey="Grafman, Jordan" sort="Grafman, Jordan" uniqKey="Grafman J" first="Jordan" last="Grafman">Jordan Grafman</name></author><author><name sortKey="Morris, Christopher M" sort="Morris, Christopher M" uniqKey="Morris C" first="Christopher M" last="Morris">Christopher M. Morris</name></author><author><name sortKey="Attems, Johannes" sort="Attems, Johannes" uniqKey="Attems J" first="Johannes" last="Attems">Johannes Attems</name></author><author><name sortKey="Griffiths, Timothy D" sort="Griffiths, Timothy D" uniqKey="Griffiths T" first="Timothy D" last="Griffiths">Timothy D. Griffiths</name></author><author><name sortKey="Mckeith, Ian G" sort="Mckeith, Ian G" uniqKey="Mckeith I" first="Ian G" last="Mckeith">Ian G. Mckeith</name></author><author><name sortKey="Thomas, Alan J" sort="Thomas, Alan J" uniqKey="Thomas A" first="Alan J" last="Thomas">Alan J. Thomas</name></author><author><name sortKey="Pietrini, P" sort="Pietrini, P" uniqKey="Pietrini P" first="P" last="Pietrini">P. Pietrini</name></author><author><name sortKey="Huey, Edward D" sort="Huey, Edward D" uniqKey="Huey E" first="Edward D" last="Huey">Edward D. Huey</name></author><author><name sortKey="Wassermann, Eric M" sort="Wassermann, Eric M" uniqKey="Wassermann E" first="Eric M" last="Wassermann">Eric M. Wassermann</name></author><author><name sortKey="Baborie, Atik" sort="Baborie, Atik" uniqKey="Baborie A" first="Atik" last="Baborie">Atik Baborie</name></author><author><name sortKey="Jaros, Evelyn" sort="Jaros, Evelyn" uniqKey="Jaros E" first="Evelyn" last="Jaros">Evelyn Jaros</name></author><author><name sortKey="Tierney, Michael C" sort="Tierney, Michael C" uniqKey="Tierney M" first="Michael C" last="Tierney">Michael C. Tierney</name></author><author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name></author><author><name sortKey="Razquin, Cristina" sort="Razquin, Cristina" uniqKey="Razquin C" first="Cristina" last="Razquin">Cristina Razquin</name></author><author><name sortKey="Ortega Cubero, Sara" sort="Ortega Cubero, Sara" uniqKey="Ortega Cubero S" first="Sara" last="Ortega-Cubero">Sara Ortega-Cubero</name></author><author><name sortKey="Alonso, Elena" sort="Alonso, Elena" uniqKey="Alonso E" first="Elena" last="Alonso">Elena Alonso</name></author><author><name sortKey="Perneczky, Robert" sort="Perneczky, Robert" uniqKey="Perneczky R" first="Robert" last="Perneczky">Robert Perneczky</name></author><author><name sortKey="Diehl Schmid, Janine" sort="Diehl Schmid, Janine" uniqKey="Diehl Schmid J" first="Janine" last="Diehl-Schmid">Janine Diehl-Schmid</name></author><author><name sortKey="Alexopoulos, Panagiotis" sort="Alexopoulos, Panagiotis" uniqKey="Alexopoulos P" first="Panagiotis" last="Alexopoulos">Panagiotis Alexopoulos</name></author><author><name sortKey="Kurz, Alexander" sort="Kurz, Alexander" uniqKey="Kurz A" first="Alexander" last="Kurz">Alexander Kurz</name></author><author><name sortKey="Rainero, Innocenzo" sort="Rainero, Innocenzo" uniqKey="Rainero I" first="Innocenzo" last="Rainero">Innocenzo Rainero</name></author><author><name sortKey="Rubino, Elisa" sort="Rubino, Elisa" uniqKey="Rubino E" first="Elisa" last="Rubino">Elisa Rubino</name></author><author><name sortKey="Pinessi, Lorenzo" sort="Pinessi, Lorenzo" uniqKey="Pinessi L" first="Lorenzo" last="Pinessi">Lorenzo Pinessi</name></author><author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name></author><author><name sortKey="George Hyslop, Peter St" sort="George Hyslop, Peter St" uniqKey="George Hyslop P" first="Peter St" last="George-Hyslop">Peter St George-Hyslop</name></author><author><name sortKey="Rossi, Giacomina" sort="Rossi, Giacomina" uniqKey="Rossi G" first="Giacomina" last="Rossi">Giacomina Rossi</name></author><author><name sortKey="Tagliavini, Fabrizio" sort="Tagliavini, Fabrizio" uniqKey="Tagliavini F" first="Fabrizio" last="Tagliavini">Fabrizio Tagliavini</name></author><author><name sortKey="Giaccone, Giorgio" sort="Giaccone, Giorgio" uniqKey="Giaccone G" first="Giorgio" last="Giaccone">Giorgio Giaccone</name></author><author><name sortKey="Rowe, James B" sort="Rowe, James B" uniqKey="Rowe J" first="James B" last="Rowe">James B. Rowe</name></author><author><name sortKey="Schlachetzki, J C M" sort="Schlachetzki, J C M" uniqKey="Schlachetzki J" first="J C M" last="Schlachetzki">J C M. Schlachetzki</name></author><author><name sortKey="Uphill, James" sort="Uphill, James" uniqKey="Uphill J" first="James" last="Uphill">James Uphill</name></author><author><name sortKey="Collinge, John" sort="Collinge, John" uniqKey="Collinge J" first="John" last="Collinge">John Collinge</name></author><author><name sortKey="Mead, S" sort="Mead, S" uniqKey="Mead S" first="S" last="Mead">S. Mead</name></author><author><name sortKey="Danek, Adrian" sort="Danek, Adrian" uniqKey="Danek A" first="Adrian" last="Danek">Adrian Danek</name></author><author><name sortKey="Van Deerlin, Vivianna M" sort="Van Deerlin, Vivianna M" uniqKey="Van Deerlin V" first="Vivianna M" last="Van Deerlin">Vivianna M. Van Deerlin</name></author><author><name sortKey="Grossman, Murray" sort="Grossman, Murray" uniqKey="Grossman M" first="Murray" last="Grossman">Murray Grossman</name></author><author><name sortKey="Trojanowsk, John Q" sort="Trojanowsk, John Q" uniqKey="Trojanowsk J" first="John Q" last="Trojanowsk">John Q. Trojanowsk</name></author><author><name sortKey="Van Der Zee, Julie" sort="Van Der Zee, Julie" uniqKey="Van Der Zee J" first="Julie" last="Van Der Zee">Julie Van Der Zee</name></author><author><name sortKey="Deschamps, William" sort="Deschamps, William" uniqKey="Deschamps W" first="William" last="Deschamps">William Deschamps</name></author><author><name sortKey="Van Langenhove, Tim" sort="Van Langenhove, Tim" uniqKey="Van Langenhove T" first="Tim" last="Van Langenhove">Tim Van Langenhove</name></author><author><name sortKey="Cruts, Marc" sort="Cruts, Marc" uniqKey="Cruts M" first="Marc" last="Cruts">Marc Cruts</name></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name></author><author><name sortKey="Cappa, Stefano F" sort="Cappa, Stefano F" uniqKey="Cappa S" first="Stefano F" last="Cappa">Stefano F. Cappa</name></author><author><name sortKey="Le Ber, Isabelle" sort="Le Ber, Isabelle" uniqKey="Le Ber I" first="Isabelle" last="Le Ber">Isabelle Le Ber</name></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name></author><author><name sortKey="Golfier, Veronique" sort="Golfier, Veronique" uniqKey="Golfier V" first="Véronique" last="Golfier">Véronique Golfier</name></author><author><name sortKey="Vercelletto, Martine" sort="Vercelletto, Martine" uniqKey="Vercelletto M" first="Martine" last="Vercelletto">Martine Vercelletto</name></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name></author><author><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name></author><author><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name></author><author><name sortKey="Bagnoli, Silvia" sort="Bagnoli, Silvia" uniqKey="Bagnoli S" first="Silvia" last="Bagnoli">Silvia Bagnoli</name></author><author><name sortKey="Piaceri, Irene" sort="Piaceri, Irene" uniqKey="Piaceri I" first="Irene" last="Piaceri">Irene Piaceri</name></author><author><name sortKey="Nielsen, J Rgen E" sort="Nielsen, J Rgen E" uniqKey="Nielsen J" first="J Rgen E" last="Nielsen">J Rgen E. Nielsen</name></author><author><name sortKey="Hjermind, Lena E" sort="Hjermind, Lena E" uniqKey="Hjermind L" first="Lena E" last="Hjermind">Lena E. Hjermind</name></author><author><name sortKey="Riemenschneider, Matthias" sort="Riemenschneider, Matthias" uniqKey="Riemenschneider M" first="Matthias" last="Riemenschneider">Matthias Riemenschneider</name></author><author><name sortKey="Mayhaus, Manuel" sort="Mayhaus, Manuel" uniqKey="Mayhaus M" first="Manuel" last="Mayhaus">Manuel Mayhaus</name></author><author><name sortKey="Ibach, Bernd" sort="Ibach, Bernd" uniqKey="Ibach B" first="Bernd" last="Ibach">Bernd Ibach</name></author><author><name sortKey="Gasparoni, Gilles" sort="Gasparoni, Gilles" uniqKey="Gasparoni G" first="Gilles" last="Gasparoni">Gilles Gasparoni</name></author><author><name sortKey="Pichler, Sabrina" sort="Pichler, Sabrina" uniqKey="Pichler S" first="Sabrina" last="Pichler">Sabrina Pichler</name></author><author><name sortKey="Gu, Wei" sort="Gu, Wei" uniqKey="Gu W" first="Wei" last="Gu">Wei Gu</name></author><author><name sortKey="Rossor, Martin N" sort="Rossor, Martin N" uniqKey="Rossor M" first="Martin N" last="Rossor">Martin N. Rossor</name></author><author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C" last="Fox">Nick C. Fox</name></author><author><name sortKey="Warren, Jason D" sort="Warren, Jason D" uniqKey="Warren J" first="Jason D" last="Warren">Jason D. Warren</name></author><author><name sortKey="Spillantini, Maria Grazia" sort="Spillantini, Maria Grazia" uniqKey="Spillantini M" first="Maria Grazia" last="Spillantini">Maria Grazia Spillantini</name></author><author><name sortKey="Morris, Huw R" sort="Morris, Huw R" uniqKey="Morris H" first="Huw R" last="Morris">Huw R. Morris</name></author><author><name sortKey="Rizzu, Patrizia" sort="Rizzu, Patrizia" uniqKey="Rizzu P" first="Patrizia" last="Rizzu">Patrizia Rizzu</name></author><author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name></author><author><name sortKey="Snowden, Julie S" sort="Snowden, Julie S" uniqKey="Snowden J" first="Julie S" last="Snowden">Julie S. Snowden</name></author><author><name sortKey="Rollinson, Sara" sort="Rollinson, Sara" uniqKey="Rollinson S" first="Sara" last="Rollinson">Sara Rollinson</name></author><author><name sortKey="Richardson, Anna" sort="Richardson, Anna" uniqKey="Richardson A" first="Anna" last="Richardson">Anna Richardson</name></author><author><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name></author><author><name sortKey="Bruni, Amalia C" sort="Bruni, Amalia C" uniqKey="Bruni A" first="Amalia C" last="Bruni">Amalia C. Bruni</name></author><author><name sortKey="Maletta, Raffaele" sort="Maletta, Raffaele" uniqKey="Maletta R" first="Raffaele" last="Maletta">Raffaele Maletta</name></author><author><name sortKey="Frangipane, Francesca" sort="Frangipane, Francesca" uniqKey="Frangipane F" first="Francesca" last="Frangipane">Francesca Frangipane</name></author><author><name sortKey="Cupidi, Chiara" sort="Cupidi, Chiara" uniqKey="Cupidi C" first="Chiara" last="Cupidi">Chiara Cupidi</name></author><author><name sortKey="Bernardi, Livia" sort="Bernardi, Livia" uniqKey="Bernardi L" first="Livia" last="Bernardi">Livia Bernardi</name></author><author><name sortKey="Anfossi, Maria" sort="Anfossi, Maria" uniqKey="Anfossi M" first="Maria" last="Anfossi">Maria Anfossi</name></author><author><name sortKey="Gallo, Maura" sort="Gallo, Maura" uniqKey="Gallo M" first="Maura" last="Gallo">Maura Gallo</name></author><author><name sortKey="Conidi, Maria Elena" sort="Conidi, Maria Elena" uniqKey="Conidi M" first="Maria Elena" last="Conidi">Maria Elena Conidi</name></author><author><name sortKey="Smirne, Nicoletta" sort="Smirne, Nicoletta" uniqKey="Smirne N" first="Nicoletta" last="Smirne">Nicoletta Smirne</name></author><author><name sortKey="Rademakers, Rosa" sort="Rademakers, Rosa" uniqKey="Rademakers R" first="Rosa" last="Rademakers">Rosa Rademakers</name></author><author><name sortKey="Baker, Matt" sort="Baker, Matt" uniqKey="Baker M" first="Matt" last="Baker">Matt Baker</name></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name></author><author><name sortKey="Graff Radford, Neill R" sort="Graff Radford, Neill R" uniqKey="Graff Radford N" first="Neill R" last="Graff-Radford">Neill R. Graff-Radford</name></author><author><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C" last="Petersen">Ronald C. Petersen</name></author><author><name sortKey="Knopman, David" sort="Knopman, David" uniqKey="Knopman D" first="David" last="Knopman">David Knopman</name></author><author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A" last="Josephs">Keith A. Josephs</name></author><author><name sortKey="Boeve, Bradley F" sort="Boeve, Bradley F" uniqKey="Boeve B" first="Bradley F" last="Boeve">Bradley F. Boeve</name></author><author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E" last="Parisi">Joseph E. Parisi</name></author><author><name sortKey="Seeley, William W" sort="Seeley, William W" uniqKey="Seeley W" first="William W" last="Seeley">William W. Seeley</name></author><author><name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L" last="Miller">Bruce L. Miller</name></author><author><name sortKey="Karydas, Anna M" sort="Karydas, Anna M" uniqKey="Karydas A" first="Anna M" last="Karydas">Anna M. Karydas</name></author><author><name sortKey="Rosen, Howard" sort="Rosen, Howard" uniqKey="Rosen H" first="Howard" last="Rosen">Howard Rosen</name></author><author><name sortKey="Van Swieten, John C" sort="Van Swieten, John C" uniqKey="Van Swieten J" first="John C" last="Van Swieten">John C. Van Swieten</name></author><author><name sortKey="Dopper, Elise G P" sort="Dopper, Elise G P" uniqKey="Dopper E" first="Elise G P" last="Dopper">Elise G P. Dopper</name></author><author><name sortKey="Seelaar, Harro" sort="Seelaar, Harro" uniqKey="Seelaar H" first="Harro" last="Seelaar">Harro Seelaar</name></author><author><name sortKey="Pijnenburg, Yolande Al" sort="Pijnenburg, Yolande Al" uniqKey="Pijnenburg Y" first="Yolande Al" last="Pijnenburg">Yolande Al Pijnenburg</name></author><author><name sortKey="Scheltens, Philip" sort="Scheltens, Philip" uniqKey="Scheltens P" first="Philip" last="Scheltens">Philip Scheltens</name></author><author><name sortKey="Logroscino, Giancarlo" sort="Logroscino, Giancarlo" uniqKey="Logroscino G" first="Giancarlo" last="Logroscino">Giancarlo Logroscino</name></author><author><name sortKey="Capozzo, Rosa" sort="Capozzo, Rosa" uniqKey="Capozzo R" first="Rosa" last="Capozzo">Rosa Capozzo</name></author><author><name sortKey="Novelli, Valeria" sort="Novelli, Valeria" uniqKey="Novelli V" first="Valeria" last="Novelli">Valeria Novelli</name></author><author><name sortKey="Puca, Annibale A" sort="Puca, Annibale A" uniqKey="Puca A" first="Annibale A" last="Puca">Annibale A. Puca</name></author><author><name sortKey="Franceschi, M" sort="Franceschi, M" uniqKey="Franceschi M" first="M" last="Franceschi">M. Franceschi</name></author><author><name sortKey="Postiglione, Alfredo" sort="Postiglione, Alfredo" uniqKey="Postiglione A" first="Alfredo" last="Postiglione">Alfredo Postiglione</name></author><author><name sortKey="Milan, Graziella" sort="Milan, Graziella" uniqKey="Milan G" first="Graziella" last="Milan">Graziella Milan</name></author><author><name sortKey="Sorrentino, Paolo" sort="Sorrentino, Paolo" uniqKey="Sorrentino P" first="Paolo" last="Sorrentino">Paolo Sorrentino</name></author><author><name sortKey="Kristiansen, Mark" sort="Kristiansen, Mark" uniqKey="Kristiansen M" first="Mark" last="Kristiansen">Mark Kristiansen</name></author><author><name sortKey="Chiang, Huei Hsin" sort="Chiang, Huei Hsin" uniqKey="Chiang H" first="Huei-Hsin" last="Chiang">Huei-Hsin Chiang</name></author><author><name sortKey="Graff, Caroline" sort="Graff, Caroline" uniqKey="Graff C" first="Caroline" last="Graff">Caroline Graff</name></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name></author><author><name sortKey="Rollin, Adeline" sort="Rollin, Adeline" uniqKey="Rollin A" first="Adeline" last="Rollin">Adeline Rollin</name></author><author><name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name></author><author><name sortKey="Lebert, Florence" sort="Lebert, Florence" uniqKey="Lebert F" first="Florence" last="Lebert">Florence Lebert</name></author><author><name sortKey="Kapogiannis, Dimitrios" sort="Kapogiannis, Dimitrios" uniqKey="Kapogiannis D" first="Dimitrios" last="Kapogiannis">Dimitrios Kapogiannis</name></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name></author><author><name sortKey="Pickering Brown, Stuart" sort="Pickering Brown, Stuart" uniqKey="Pickering Brown S" first="Stuart" last="Pickering-Brown">Stuart Pickering-Brown</name></author><author><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B" last="Singleton">Andrew B. Singleton</name></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name></author><author><name sortKey="Momeni, Parastoo" sort="Momeni, Parastoo" uniqKey="Momeni P" first="Parastoo" last="Momeni">Parastoo Momeni</name></author></analytic><series><title level="j">Lancet neurology</title><idno type="ISSN">1474-4422</idno><idno type="eISSN">1474-4465</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Frontotemporal Dementia (classification)</term><term>Frontotemporal Dementia (diagnosis)</term><term>Frontotemporal Dementia (genetics)</term><term>Genome-Wide Association Study (methods)</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Démence frontotemporale ()</term><term>Démence frontotemporale (diagnostic)</term><term>Démence frontotemporale (génétique)</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Étude d'association pangénomique ()</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Frontotemporal Dementia</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Frontotemporal Dementia</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Démence frontotemporale</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Frontotemporal Dementia</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Démence frontotemporale</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genome-Wide Association Study</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Démence frontotemporale</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Étude d'association pangénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><sec id="S1"><title>Background</title><p id="P3">Frontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological signatures, and genetic variability. Mutations in three genes—<italic>MAPT, GRN,</italic> and <italic>C9orf72</italic>—have been associated with FTD. We sought to identify novel genetic risk loci associated with the disorder.</p></sec><sec id="S2"><title>Methods</title><p id="P4">We did a two-stage genome-wide association study on clinical FTD, analysing samples from 3526 patients with FTD and 9402 healthy controls. All participants had European ancestry. In the discovery phase (samples from 2154 patients with FTD and 4308 controls), we did separate association analyses for each FTD subtype (behavioural variant FTD, semantic dementia, progressive non-fluent aphasia, and FTD overlapping with motor neuron disease [FTD-MND]), followed by a meta-analysis of the entire dataset. We carried forward replication of the novel suggestive loci in an independent sample series (samples from 1372 patients and 5094 controls) and then did joint phase and brain expression and methylation quantitative trait loci analyses for the associated (p<5 × 10<sup>−8</sup>) and suggestive single-nucleotide polymorphisms.</p></sec><sec id="S3"><title>Findings</title><p id="P5">We identified novel associations exceeding the genome-wide significance threshold (p<5 × 10<sup>−8</sup>) that encompassed the <italic>HLA</italic> locus at 6p21.3 in the entire cohort. We also identified a potential novel locus at 11q14, encompassing <italic>RAB38/CTSC</italic>, for the behavioural FTD subtype. Analysis of expression and methylation quantitative trait loci data suggested that these loci might affect expression and methylation <italic>incis</italic>.</p></sec><sec id="S4"><title>Interpretation</title><p id="P6">Our findings suggest that immune system processes (link to 6p21.3) and possibly lysosomal and autophagy pathways (link to 11q14) are potentially involved in FTD. Our findings need to be replicated to better define the association of the newly identified loci with disease and possibly to shed light on the pathomechanisms contributing to FTD.</p></sec><sec id="S5"><title>Funding</title><p id="P7">The National Institute of Neurological Disorders and Stroke and National Institute on Aging, the Wellcome/ MRC Centre on Parkinson’s disease, Alzheimer’s Research UK, and Texas Tech University Health Sciences Center.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Alexopoulos, Panagiotis" sort="Alexopoulos, Panagiotis" uniqKey="Alexopoulos P" first="Panagiotis" last="Alexopoulos">Panagiotis Alexopoulos</name><name sortKey="Alonso, Elena" sort="Alonso, Elena" uniqKey="Alonso E" first="Elena" last="Alonso">Elena Alonso</name><name sortKey="Anfossi, Maria" sort="Anfossi, Maria" uniqKey="Anfossi M" first="Maria" last="Anfossi">Maria Anfossi</name><name sortKey="Attems, Johannes" sort="Attems, Johannes" uniqKey="Attems J" first="Johannes" last="Attems">Johannes Attems</name><name sortKey="Baborie, Atik" sort="Baborie, Atik" uniqKey="Baborie A" first="Atik" last="Baborie">Atik Baborie</name><name sortKey="Bagnoli, Silvia" sort="Bagnoli, Silvia" uniqKey="Bagnoli S" first="Silvia" last="Bagnoli">Silvia Bagnoli</name><name sortKey="Baker, Matt" sort="Baker, Matt" uniqKey="Baker M" first="Matt" last="Baker">Matt Baker</name><name sortKey="Bartley, Lauren" sort="Bartley, Lauren" uniqKey="Bartley L" first="Lauren" last="Bartley">Lauren Bartley</name><name sortKey="Benussi, Luisa" sort="Benussi, Luisa" uniqKey="Benussi L" first="Luisa" last="Benussi">Luisa Benussi</name><name sortKey="Bernardi, Livia" sort="Bernardi, Livia" uniqKey="Bernardi L" first="Livia" last="Bernardi">Livia Bernardi</name><name sortKey="Binetti, Giuliano" sort="Binetti, Giuliano" uniqKey="Binetti G" first="Giuliano" last="Binetti">Giuliano Binetti</name><name sortKey="Blesa, Rafael" sort="Blesa, Rafael" uniqKey="Blesa R" first="Rafael" last="Blesa">Rafael Blesa</name><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name><name sortKey="Boeve, Bradley F" sort="Boeve, Bradley F" uniqKey="Boeve B" first="Bradley F" last="Boeve">Bradley F. Boeve</name><name sortKey="Borroni, Barbara" sort="Borroni, Barbara" uniqKey="Borroni B" first="Barbara" last="Borroni">Barbara Borroni</name><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Brooks, William S" sort="Brooks, William S" uniqKey="Brooks W" first="William S" last="Brooks">William S. Brooks</name><name sortKey="Bruni, Amalia C" sort="Bruni, Amalia C" uniqKey="Bruni A" first="Amalia C" last="Bruni">Amalia C. Bruni</name><name sortKey="Cairns, Nigel J" sort="Cairns, Nigel J" uniqKey="Cairns N" first="Nigel J" last="Cairns">Nigel J. Cairns</name><name sortKey="Capozzo, Rosa" sort="Capozzo, Rosa" uniqKey="Capozzo R" first="Rosa" last="Capozzo">Rosa Capozzo</name><name sortKey="Cappa, Stefano F" sort="Cappa, Stefano F" uniqKey="Cappa S" first="Stefano F" last="Cappa">Stefano F. Cappa</name><name sortKey="Chiang, Huei Hsin" sort="Chiang, Huei Hsin" uniqKey="Chiang H" first="Huei-Hsin" last="Chiang">Huei-Hsin Chiang</name><name sortKey="Clarim N, Jordi" sort="Clarim N, Jordi" uniqKey="Clarim N J" first="Jordi" last="Clarim N">Jordi Clarim N</name><name sortKey="Collinge, John" sort="Collinge, John" uniqKey="Collinge J" first="John" last="Collinge">John Collinge</name><name sortKey="Conidi, Maria Elena" sort="Conidi, Maria Elena" uniqKey="Conidi M" first="Maria Elena" last="Conidi">Maria Elena Conidi</name><name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name><name sortKey="Cruts, Marc" sort="Cruts, Marc" uniqKey="Cruts M" first="Marc" last="Cruts">Marc Cruts</name><name sortKey="Cupidi, Chiara" sort="Cupidi, Chiara" uniqKey="Cupidi C" first="Chiara" last="Cupidi">Chiara Cupidi</name><name sortKey="Danek, Adrian" sort="Danek, Adrian" uniqKey="Danek A" first="Adrian" last="Danek">Adrian Danek</name><name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name><name sortKey="Deschamps, William" sort="Deschamps, William" uniqKey="Deschamps W" first="William" last="Deschamps">William Deschamps</name><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name><name sortKey="Diehl Schmid, Janine" sort="Diehl Schmid, Janine" uniqKey="Diehl Schmid J" first="Janine" last="Diehl-Schmid">Janine Diehl-Schmid</name><name sortKey="Dobson Stone, Carol" sort="Dobson Stone, Carol" uniqKey="Dobson Stone C" first="Carol" last="Dobson-Stone">Carol Dobson-Stone</name><name sortKey="Dopper, Elise G P" sort="Dopper, Elise G P" uniqKey="Dopper E" first="Elise G P" last="Dopper">Elise G P. Dopper</name><name sortKey="Fenoglio, Chiara" sort="Fenoglio, Chiara" uniqKey="Fenoglio C" first="Chiara" last="Fenoglio">Chiara Fenoglio</name><name sortKey="Ferrari, Raffaele" sort="Ferrari, Raffaele" uniqKey="Ferrari R" first="Raffaele" last="Ferrari">Raffaele Ferrari</name><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><name sortKey="Forloni, Gianluigi" sort="Forloni, Gianluigi" uniqKey="Forloni G" first="Gianluigi" last="Forloni">Gianluigi Forloni</name><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C" last="Fox">Nick C. Fox</name><name sortKey="Franceschi, M" sort="Franceschi, M" uniqKey="Franceschi M" first="M" last="Franceschi">M. Franceschi</name><name sortKey="Frangipane, Francesca" sort="Frangipane, Francesca" uniqKey="Frangipane F" first="Francesca" last="Frangipane">Francesca Frangipane</name><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><name sortKey="Gallo, Maura" sort="Gallo, Maura" uniqKey="Gallo M" first="Maura" last="Gallo">Maura Gallo</name><name sortKey="Gasparoni, Gilles" sort="Gasparoni, Gilles" uniqKey="Gasparoni G" first="Gilles" last="Gasparoni">Gilles Gasparoni</name><name sortKey="George Hyslop, Peter St" sort="George Hyslop, Peter St" uniqKey="George Hyslop P" first="Peter St" last="George-Hyslop">Peter St George-Hyslop</name><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name><name sortKey="Ghidoni, Roberta" sort="Ghidoni, Roberta" uniqKey="Ghidoni R" first="Roberta" last="Ghidoni">Roberta Ghidoni</name><name sortKey="Giaccone, Giorgio" sort="Giaccone, Giorgio" uniqKey="Giaccone G" first="Giorgio" last="Giaccone">Giorgio Giaccone</name><name sortKey="Golfier, Veronique" sort="Golfier, Veronique" uniqKey="Golfier V" first="Véronique" last="Golfier">Véronique Golfier</name><name sortKey="Graff Radford, Neill R" sort="Graff Radford, Neill R" uniqKey="Graff Radford N" first="Neill R" last="Graff-Radford">Neill R. Graff-Radford</name><name sortKey="Graff, Caroline" sort="Graff, Caroline" uniqKey="Graff C" first="Caroline" last="Graff">Caroline Graff</name><name sortKey="Grafman, Jordan" sort="Grafman, Jordan" uniqKey="Grafman J" first="Jordan" last="Grafman">Jordan Grafman</name><name sortKey="Griffiths, Timothy D" sort="Griffiths, Timothy D" uniqKey="Griffiths T" first="Timothy D" last="Griffiths">Timothy D. Griffiths</name><name sortKey="Grossman, Murray" sort="Grossman, Murray" uniqKey="Grossman M" first="Murray" last="Grossman">Murray Grossman</name><name sortKey="Gu, Wei" sort="Gu, Wei" uniqKey="Gu W" first="Wei" last="Gu">Wei Gu</name><name sortKey="Haan, Eric" sort="Haan, Eric" uniqKey="Haan E" first="Eric" last="Haan">Eric Haan</name><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M" last="Halliday">Glenda M. Halliday</name><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><name sortKey="Hernandez, Dena G" sort="Hernandez, Dena G" uniqKey="Hernandez D" first="Dena G" last="Hernandez">Dena G. Hernandez</name><name sortKey="Hernandez, Isabel" sort="Hernandez, Isabel" uniqKey="Hernandez I" first="Isabel" last="Hernández">Isabel Hernández</name><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name><name sortKey="Hjermind, Lena E" sort="Hjermind, Lena E" uniqKey="Hjermind L" first="Lena E" last="Hjermind">Lena E. Hjermind</name><name sortKey="Hodges, John R" sort="Hodges, John R" uniqKey="Hodges J" first="John R" last="Hodges">John R. Hodges</name><name sortKey="Hsiung, Ging Yuek R" sort="Hsiung, Ging Yuek R" uniqKey="Hsiung G" first="Ging-Yuek R" last="Hsiung">Ging-Yuek R. Hsiung</name><name sortKey="Huey, Edward D" sort="Huey, Edward D" uniqKey="Huey E" first="Edward D" last="Huey">Edward D. Huey</name><name sortKey="Ibach, Bernd" sort="Ibach, Bernd" uniqKey="Ibach B" first="Bernd" last="Ibach">Bernd Ibach</name><name sortKey="Jaros, Evelyn" sort="Jaros, Evelyn" uniqKey="Jaros E" first="Evelyn" last="Jaros">Evelyn Jaros</name><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A" last="Josephs">Keith A. Josephs</name><name sortKey="Kapogiannis, Dimitrios" sort="Kapogiannis, Dimitrios" uniqKey="Kapogiannis D" first="Dimitrios" last="Kapogiannis">Dimitrios Kapogiannis</name><name sortKey="Karydas, Anna M" sort="Karydas, Anna M" uniqKey="Karydas A" first="Anna M" last="Karydas">Anna M. Karydas</name><name sortKey="Knopman, David" sort="Knopman, David" uniqKey="Knopman D" first="David" last="Knopman">David Knopman</name><name sortKey="Kristiansen, Mark" sort="Kristiansen, Mark" uniqKey="Kristiansen M" first="Mark" last="Kristiansen">Mark Kristiansen</name><name sortKey="Kurz, Alexander" sort="Kurz, Alexander" uniqKey="Kurz A" first="Alexander" last="Kurz">Alexander Kurz</name><name sortKey="Kwok, John B J" sort="Kwok, John B J" uniqKey="Kwok J" first="John B J" last="Kwok">John B J. Kwok</name><name sortKey="Le Ber, Isabelle" sort="Le Ber, Isabelle" uniqKey="Le Ber I" first="Isabelle" last="Le Ber">Isabelle Le Ber</name><name sortKey="Lebert, Florence" sort="Lebert, Florence" uniqKey="Lebert F" first="Florence" last="Lebert">Florence Lebert</name><name sortKey="Lle, Alberto" sort="Lle, Alberto" uniqKey="Lle A" first="Alberto" last="Lle">Alberto Lle</name><name sortKey="Logroscino, Giancarlo" sort="Logroscino, Giancarlo" uniqKey="Logroscino G" first="Giancarlo" last="Logroscino">Giancarlo Logroscino</name><name sortKey="Mackenzie, Ian R A" sort="Mackenzie, Ian R A" uniqKey="Mackenzie I" first="Ian R A" last="Mackenzie">Ian R A. Mackenzie</name><name sortKey="Maletta, Raffaele" sort="Maletta, Raffaele" uniqKey="Maletta R" first="Raffaele" last="Maletta">Raffaele Maletta</name><name sortKey="Mann, David M A" sort="Mann, David M A" uniqKey="Mann D" first="David M A" last="Mann">David M A. Mann</name><name sortKey="Mayhaus, Manuel" sort="Mayhaus, Manuel" uniqKey="Mayhaus M" first="Manuel" last="Mayhaus">Manuel Mayhaus</name><name sortKey="Mckeith, Ian G" sort="Mckeith, Ian G" uniqKey="Mckeith I" first="Ian G" last="Mckeith">Ian G. Mckeith</name><name sortKey="Mead, S" sort="Mead, S" uniqKey="Mead S" first="S" last="Mead">S. Mead</name><name sortKey="Milan, Graziella" sort="Milan, Graziella" uniqKey="Milan G" first="Graziella" last="Milan">Graziella Milan</name><name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L" last="Miller">Bruce L. Miller</name><name sortKey="Momeni, Parastoo" sort="Momeni, Parastoo" uniqKey="Momeni P" first="Parastoo" last="Momeni">Parastoo Momeni</name><name sortKey="Morris, Christopher M" sort="Morris, Christopher M" uniqKey="Morris C" first="Christopher M" last="Morris">Christopher M. Morris</name><name sortKey="Morris, Huw R" sort="Morris, Huw R" uniqKey="Morris H" first="Huw R" last="Morris">Huw R. Morris</name><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A" last="Nalls">Michael A. Nalls</name><name sortKey="Nielsen, J Rgen E" sort="Nielsen, J Rgen E" uniqKey="Nielsen J" first="J Rgen E" last="Nielsen">J Rgen E. Nielsen</name><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><name sortKey="Nilsson, Karin" sort="Nilsson, Karin" uniqKey="Nilsson K" first="Karin" last="Nilsson">Karin Nilsson</name><name sortKey="Novelli, Valeria" sort="Novelli, Valeria" uniqKey="Novelli V" first="Valeria" last="Novelli">Valeria Novelli</name><name sortKey="Ortega Cubero, Sara" sort="Ortega Cubero, Sara" uniqKey="Ortega Cubero S" first="Sara" last="Ortega-Cubero">Sara Ortega-Cubero</name><name sortKey="Padovani, Alessandro" sort="Padovani, Alessandro" uniqKey="Padovani A" first="Alessandro" last="Padovani">Alessandro Padovani</name><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E" last="Parisi">Joseph E. Parisi</name><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name><name sortKey="Perneczky, Robert" sort="Perneczky, Robert" uniqKey="Perneczky R" first="Robert" last="Perneczky">Robert Perneczky</name><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C" last="Petersen">Ronald C. Petersen</name><name sortKey="Piaceri, Irene" sort="Piaceri, Irene" uniqKey="Piaceri I" first="Irene" last="Piaceri">Irene Piaceri</name><name sortKey="Pichler, Sabrina" sort="Pichler, Sabrina" uniqKey="Pichler S" first="Sabrina" last="Pichler">Sabrina Pichler</name><name sortKey="Pickering Brown, Stuart" sort="Pickering Brown, Stuart" uniqKey="Pickering Brown S" first="Stuart" last="Pickering-Brown">Stuart Pickering-Brown</name><name sortKey="Pietrini, P" sort="Pietrini, P" uniqKey="Pietrini P" first="P" last="Pietrini">P. Pietrini</name><name sortKey="Piguet, Olivier" sort="Piguet, Olivier" uniqKey="Piguet O" first="Olivier" last="Piguet">Olivier Piguet</name><name sortKey="Pijnenburg, Yolande Al" sort="Pijnenburg, Yolande Al" uniqKey="Pijnenburg Y" first="Yolande Al" last="Pijnenburg">Yolande Al Pijnenburg</name><name sortKey="Pinessi, Lorenzo" sort="Pinessi, Lorenzo" uniqKey="Pinessi L" first="Lorenzo" last="Pinessi">Lorenzo Pinessi</name><name sortKey="Postiglione, Alfredo" sort="Postiglione, Alfredo" uniqKey="Postiglione A" first="Alfredo" last="Postiglione">Alfredo Postiglione</name><name sortKey="Puca, Annibale A" sort="Puca, Annibale A" uniqKey="Puca A" first="Annibale A" last="Puca">Annibale A. Puca</name><name sortKey="Rademakers, Rosa" sort="Rademakers, Rosa" uniqKey="Rademakers R" first="Rosa" last="Rademakers">Rosa Rademakers</name><name sortKey="Rainero, Innocenzo" sort="Rainero, Innocenzo" uniqKey="Rainero I" first="Innocenzo" last="Rainero">Innocenzo Rainero</name><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><name sortKey="Razquin, Cristina" sort="Razquin, Cristina" uniqKey="Razquin C" first="Cristina" last="Razquin">Cristina Razquin</name><name sortKey="Richardson, Anna" sort="Richardson, Anna" uniqKey="Richardson A" first="Anna" last="Richardson">Anna Richardson</name><name sortKey="Riemenschneider, Matthias" sort="Riemenschneider, Matthias" uniqKey="Riemenschneider M" first="Matthias" last="Riemenschneider">Matthias Riemenschneider</name><name sortKey="Rizzu, Patrizia" sort="Rizzu, Patrizia" uniqKey="Rizzu P" first="Patrizia" last="Rizzu">Patrizia Rizzu</name><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name><name sortKey="Rohrer, Jonathan D" sort="Rohrer, Jonathan D" uniqKey="Rohrer J" first="Jonathan D" last="Rohrer">Jonathan D. Rohrer</name><name sortKey="Rollin, Adeline" sort="Rollin, Adeline" uniqKey="Rollin A" first="Adeline" last="Rollin">Adeline Rollin</name><name sortKey="Rollinson, Sara" sort="Rollinson, Sara" uniqKey="Rollinson S" first="Sara" last="Rollinson">Sara Rollinson</name><name sortKey="Rosen, Howard" sort="Rosen, Howard" uniqKey="Rosen H" first="Howard" last="Rosen">Howard Rosen</name><name sortKey="Rossi, Giacomina" sort="Rossi, Giacomina" uniqKey="Rossi G" first="Giacomina" last="Rossi">Giacomina Rossi</name><name sortKey="Rossor, Martin N" sort="Rossor, Martin N" uniqKey="Rossor M" first="Martin N" last="Rossor">Martin N. Rossor</name><name sortKey="Rowe, James B" sort="Rowe, James B" uniqKey="Rowe J" first="James B" last="Rowe">James B. Rowe</name><name sortKey="Rubino, Elisa" sort="Rubino, Elisa" uniqKey="Rubino E" first="Elisa" last="Rubino">Elisa Rubino</name><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustín" last="Ruiz">Agustín Ruiz</name><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name><name sortKey="Scheltens, Philip" sort="Scheltens, Philip" uniqKey="Scheltens P" first="Philip" last="Scheltens">Philip Scheltens</name><name sortKey="Schlachetzki, J C M" sort="Schlachetzki, J C M" uniqKey="Schlachetzki J" first="J C M" last="Schlachetzki">J C M. Schlachetzki</name><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R" last="Schofield">Peter R. Schofield</name><name sortKey="Seelaar, Harro" sort="Seelaar, Harro" uniqKey="Seelaar H" first="Harro" last="Seelaar">Harro Seelaar</name><name sortKey="Seeley, William W" sort="Seeley, William W" uniqKey="Seeley W" first="William W" last="Seeley">William W. Seeley</name><name sortKey="Serpente, Maria" sort="Serpente, Maria" uniqKey="Serpente M" first="Maria" last="Serpente">Maria Serpente</name><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B" last="Singleton">Andrew B. Singleton</name><name sortKey="Smirne, Nicoletta" sort="Smirne, Nicoletta" uniqKey="Smirne N" first="Nicoletta" last="Smirne">Nicoletta Smirne</name><name sortKey="Snowden, Julie S" sort="Snowden, Julie S" uniqKey="Snowden J" first="Julie S" last="Snowden">Julie S. Snowden</name><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><name sortKey="Sorrentino, Paolo" sort="Sorrentino, Paolo" uniqKey="Sorrentino P" first="Paolo" last="Sorrentino">Paolo Sorrentino</name><name sortKey="Spillantini, Maria Grazia" sort="Spillantini, Maria Grazia" uniqKey="Spillantini M" first="Maria Grazia" last="Spillantini">Maria Grazia Spillantini</name><name sortKey="Tagliavini, Fabrizio" sort="Tagliavini, Fabrizio" uniqKey="Tagliavini F" first="Fabrizio" last="Tagliavini">Fabrizio Tagliavini</name><name sortKey="Thomas, Alan J" sort="Thomas, Alan J" uniqKey="Thomas A" first="Alan J" last="Thomas">Alan J. Thomas</name><name sortKey="Thompson, Elizabeth" sort="Thompson, Elizabeth" uniqKey="Thompson E" first="Elizabeth" last="Thompson">Elizabeth Thompson</name><name sortKey="Tierney, Michael C" sort="Tierney, Michael C" uniqKey="Tierney M" first="Michael C" last="Tierney">Michael C. Tierney</name><name sortKey="Trojanowsk, John Q" sort="Trojanowsk, John Q" uniqKey="Trojanowsk J" first="John Q" last="Trojanowsk">John Q. Trojanowsk</name><name sortKey="Uphill, James" sort="Uphill, James" uniqKey="Uphill J" first="James" last="Uphill">James Uphill</name><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><name sortKey="Van Deerlin, Vivianna M" sort="Van Deerlin, Vivianna M" uniqKey="Van Deerlin V" first="Vivianna M" last="Van Deerlin">Vivianna M. Van Deerlin</name><name sortKey="Van Der Zee, Julie" sort="Van Der Zee, Julie" uniqKey="Van Der Zee J" first="Julie" last="Van Der Zee">Julie Van Der Zee</name><name sortKey="Van Langenhove, Tim" sort="Van Langenhove, Tim" uniqKey="Van Langenhove T" first="Tim" last="Van Langenhove">Tim Van Langenhove</name><name sortKey="Van Swieten, John C" sort="Van Swieten, John C" uniqKey="Van Swieten J" first="John C" last="Van Swieten">John C. Van Swieten</name><name sortKey="Vercelletto, Martine" sort="Vercelletto, Martine" uniqKey="Vercelletto M" first="Martine" last="Vercelletto">Martine Vercelletto</name><name sortKey="Waldo, Maria Landqvist" sort="Waldo, Maria Landqvist" uniqKey="Waldo M" first="Maria Landqvist" last="Waldö">Maria Landqvist Waldö</name><name sortKey="Warren, Jason D" sort="Warren, Jason D" uniqKey="Warren J" first="Jason D" last="Warren">Jason D. Warren</name><name sortKey="Wassermann, Eric M" sort="Wassermann, Eric M" uniqKey="Wassermann E" first="Eric M" last="Wassermann">Eric M. Wassermann</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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